“The entourage hypothesis holds that cannabis constituents interact to engender greater effects but there is little scientific evidence to support such an assertion. Our study shows that different cannabinoids interact to alter plasma levels of cannabinoids themselves due to what we call a ‘pharmacokinetic entourage’ effect”.
Low-dose CBD products appear to reduce anxiety and are anticonvulsant agents against seizures. But it remains unclear how these products produce these results.
Lead author of the study, Dr Lyndsey Anderson, said: “Our results suggest CBDA might play a greater role in the effects of these low-dose CBD products than previously thought. Our own preclinical studies show CBDA reduces anxiety and seizures. This result provides us with a pathway to explore why some cannabis extracts yield pharmacological effects in humans at lower doses.”
The scientists will continue to work on how this “pharmacokinetic entourage effect” might lead to observed therapeutic outcomes for cannabinoids in people.
The study is published today in Scientific Reports.
This study was funded by the Lambert Initiative for Cannabinoid Therapeutics and the Australian National Health and Medical Research Council.
About the Lambert Initiative
The Lambert Initiative for Cannabinoid Therapeutics at the University of Sydney provides national and international leadership both in the science of medicinal cannabis and in the discovery and development of cannabis-based medicines.
It was established thanks to a philanthropic donation by Barry and Joy Lambert.
Credit: Source link